association between neuregulin-1 gene variant ‎‎(rs2439272) and schizophrenia and its negative ‎symptoms in an iranian population

objective: although the etiology of schizophrenia is unknown, it has a significant genetic component. ‎a number of studies have indicated that neuregulin-1 (nrg1) gene may play a role in the ‎pathogenesis of schizophrenia. in this study, we examined whether the rs2439272 of nrg1 ‎is associated with schizophrenia and its negative symptoms in an iranian population.‎ method: rs2439272 was genotyped in 469 participants including 276 unrelated patients with schizophrenia and 193 healthy controls. the association of genetic risk with panss, and negative ‎symptoms was examined in the total, male and female samples. cocaphase and ‎clump22 programs were used to compare the allele and genotype frequencies, and ‎general linear regression was used to analyze the quantitative dependent variables by the ‎selected variant.‎ results: in this study, it was revealed that the g allele of rs2439272 might be an allele with the ‎increased risk of developing schizophrenia, especially in the male participants. in addition, ‎significant differences were found between the g allele and gg genotype frequencies and ‎panss, and negative symptoms in the total and male participants.‎ conclusion: our results supported the association between rs2439272 in nrg1 gene and risk of ‎schizophrenia and its negative symptoms in an iranian population.